Gene information
Official symbol IL12A
Official full name interleukin 12A
Gene type protein-coding gene
Chromosome3q25.33
Alias symbolCLMF|IL-12A|p35|NFSK
Previous symbolNKSF1
Gene familyInterleukins
Resources
Entrez Gene 3592
HGNC HGNC:5969
Ensembl ENSG00000168811
Vega OTTHUMG00000158942
UCSC uc003fcx.4
GO terms: 123 records
GO Description Category LogP Number of genes Detail
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001910 regulation of leukocyte mediated cytotoxicity GO Biological Processes -7.82450130 11 More
GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO Biological Processes -3.17989306 9 More
GO:0001914 regulation of T cell mediated cytotoxicity GO Biological Processes -2.74076564 4 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002711 positive regulation of T cell mediated immunity GO Biological Processes -6.00483593 8 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002833 positive regulation of response to biotic stimulus GO Biological Processes -5.95822718 13 More
GO:0002834 regulation of response to tumor cell GO Biological Processes -3.75695916 4 More
GO:0002836 positive regulation of response to tumor cell GO Biological Processes -3.04620727 3 More
GO:0002837 regulation of immune response to tumor cell GO Biological Processes -3.92689699 4 More
GO:0002839 positive regulation of immune response to tumor cell GO Biological Processes -3.04620727 3 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005770 late endosome GO Cellular Components -2.28850711 22 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010660 regulation of muscle cell apoptotic process GO Biological Processes -26.1774267 35 More
GO:0010661 positive regulation of muscle cell apoptotic process GO Biological Processes -13.2907676 16 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031341 regulation of cell killing GO Biological Processes -10.2641102 14 More
GO:0031343 positive regulation of cell killing GO Biological Processes -3.44182824 10 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031904 endosome lumen GO Cellular Components -9.27147512 9 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032649 regulation of interferon-gamma production GO Biological Processes -12.4733429 27 More
GO:0032660 regulation of interleukin-17 production GO Biological Processes -6.79373102 8 More
GO:0032700 negative regulation of interleukin-17 production GO Biological Processes -3.75695916 4 More
GO:0032814 regulation of natural killer cell activation GO Biological Processes -6.02130395 7 More
GO:0032816 positive regulation of natural killer cell activation GO Biological Processes -3.53254248 4 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0034391 regulation of smooth muscle cell apoptotic process GO Biological Processes -12.4801943 15 More
GO:0034393 positive regulation of smooth muscle cell apoptotic process GO Biological Processes -5.72938190 7 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0045088 regulation of innate immune response GO Biological Processes -6.98001665 16 More
GO:0045089 positive regulation of innate immune response GO Biological Processes -3.90916833 9 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0046982 protein heterodimerization activity GO Molecular Functions -2.81006698 12 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048662 negative regulation of smooth muscle cell proliferation GO Biological Processes -21.7509412 30 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050709 negative regulation of protein secretion GO Biological Processes -12.5236372 21 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051224 negative regulation of protein transport GO Biological Processes -11.0190941 26 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071675 regulation of mononuclear cell migration GO Biological Processes -19.9332328 23 More
GO:0071677 positive regulation of mononuclear cell migration GO Biological Processes -15.5919825 16 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090288 negative regulation of cellular response to growth factor stimulus GO Biological Processes -9.39414218 23 More
GO:0097190 apoptotic signaling pathway GO Biological Processes -11.7839485 23 More
GO:0097191 extrinsic apoptotic signaling pathway GO Biological Processes -9.74858067 13 More
GO:0098586 cellular response to virus GO Biological Processes -6.52248641 17 More
GO:1900746 regulation of vascular endothelial growth factor signaling pathway GO Biological Processes -8.31468142 11 More
GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus GO Biological Processes -7.92453051 11 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903531 negative regulation of secretion by cell GO Biological Processes -17.4034654 36 More
GO:1903828 negative regulation of protein localization GO Biological Processes -8.86943289 30 More
GO:1904950 negative regulation of establishment of protein localization GO Biological Processes -11.4813166 27 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 20 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04622 RIG-I-like receptor signaling pathway KEGG Pathway -3.50554828 6 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04658 Th1 and Th2 cell differentiation KEGG Pathway -5.18694144 15 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa04940 Type I diabetes mellitus KEGG Pathway -8.40921139 9 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05330 Allograft rejection KEGG Pathway -10.3501019 10 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
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Related drugs: 4 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
interleukin-12 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Belenkova Y et al. J Inflamm Res. 2015
interleukin-12 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Belenkova Y et al. J Inflamm Res. 2015
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